CERES NANOSCIENCE EXPANSION

Client: Facility Logix
Location: Manassas, VA
Size: 12,000 SF

MEP design and CA for the expansion of Ceres NanoScience’s production facility in a new 12,000 SF space in Manassas, VA. The space includes an office area, four (4) production labs, chemical/reagents/raw material storage room, DI water supply and waste storage room, packing and shipping room, QA/QC lab, QC holding room, restrooms, a gowning room, a pantry/common area, and a reception area. Plumbing design included a new DI water system, new waste drainage system and piping connections to external waste storage tank, domestic water piping and connections for standard lab fixtures, restrooms, and pantry, backflow prevention to separate the office and lab water systems, recirculating pumping systems, gas fired water heating equipment, and natural gas piping to RTU’s. Mechanical design included new rooftop units, split systems and general exhaust systems, etc. Electrical design included new electrical distribution systems, lighting, and fire alarm systems, new emergency generator to serve the HVAC and user’s equipment, and modifications to existing low voltage and security systems.

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NIH | BUILDING 10 i-IVAU EXPANSION AND HAZARDOUS DRUG STORAGE

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 3,000 SF

This project included MEP engineering design services for the relocation of existing pharmacy functions and hazardous drug storage to the I-IVAU area in Building 10, approximately3,000 SF. Design also includes three (3) related projects; an expansion of the existing I-IVAU facility, a buildout of a hazardous drug storage area, and a new mechanical room to support the new areas. New spaces in the I-IVAU Pharmacy suite include the HD storage room, a drug storage room, a USP 797 production room, a USP 797 airlock room, a USP 797 anteroom, a USP 800 production room, a USP 800 airlock room, a USP 800 anteroom, a Reese storage room, the I-IVAU mechanical room, and a receiving office.

The mechanical design included modifications to the supply air and exhaust air systems and new connections to the existing 100% outside air AHUs and existing exhaust fans. New fast acting venturi valve type terminal units with hydronic reheat coils to control space temperatures and maintain pressurization and air change rates were designed. A new medium pressure supply air and exhaust air main was also provided. All ISO 7 and ISO 8 Classified and Controlled-Not-Classified (CNC) spaces within the suite are served by terminal ULPA filter diffusers. Design also included new VAV terminal units with integral reheat coils to control temperatures for the administrative spaces. Additionally, modifications to the existing hydronic heating hot water system to serve reheat coils at each of the supply air terminals as well as new hydronic piping, coils and valves were made. A new branch from the existing heating hot water system was also provided.  A new Environmental Monitoring System and new DDC controls tied back to the existing BAS were designed for the Pharmacy suite.

The plumbing design includes modifications of the existing domestic cold/hot water, sanitary and vent piping systems, high purity water system, and Nitrogen and Argon gas systems with new plumbing connections and distribution piping to new equipment, sinks and emergency eyewash stations. The electrical design includes new normal and emergency power receptacles provided by existing normal and emergency panelboards, new voice and data infrastructure, modifications to the fire alarm system with new devices for proper coverage, a new aspiration smoke detection system for the ISO 7, ISO 8 and CNC spaces, and new cleanroom rated LED lighting fixtures and controls.

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sUPERNUS PHARMACEUTICALS

Client: Supernus
Location: Rockville, MD
Size: 136,000 SF

This project included MEP engineering design services and construction administration services for the interior fit-out of   approximately 136,000 SF of office, lab and GMP space between two (2) buildings and five (5) floors between them. Renovations to the first floor included typical office space for multiple departments with a mix of private offices, open office workstations, conference rooms, reception area,storage/file rooms, a large lunchroom, a fitness center and men’s and women’s locker rooms. The 2nd floor included both typical office space, as well as lab and GMP spaces required for pharmaceutical manufacturing. The penthouse renovations included a new pilot plant to be used for Phase 1 and Phase 2 trials. CFR provided extensive design modifications to the existing MEP systems necessary to accommodate the new spaces. The base building systems required heavy upgrades including but not limited to new VAV units, new AHUs, new exhaust systems, new gas water heaters, new lab gasses, a new emergency generator, and a new fire alarm system. Mechanical design also included a new recirculating packaged RTU for the lab areas, new DOAS single pass RTU for the pilot plant, humidification systems, new steam process boiler, all room pressurization and control systems, all branch ductwork, diffusers and HEPA filtering systems.

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NIH | BUILDING 29 COMPLEX RENOVATIONS

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 60,000 SF

This project included the design study for a renovation of newly assigned space in Building 29B for five (5) NIAID personnel. The renovated space will house staff scientists and support staff and will accommodate general purpose laboratories, bio-safety level laboratories, shared analytical laboratories, and administrative support spaces. The renovation includes space on floors 1-5 and the basement of Building 29B. Total square footage is approximately 60,000 SF. Since the completion of the design study, NIH has also awarded the CFR team the design and post-design services for this project.CFR is the prime consultant on this project providing project management and MEP engineering design services. This project was also designed along with other sub-consultants including; architecture, structural engineering, and cost estimating services. Specialized third party services for testing and balancing services as well as autoclave testing services of all autoclaves on the 2nd, 3rd, 4th and 5th floors of the Building were provided.Additional specialized third party services for cGMP technical support for the relocation of the NIAID clean room facility to the basement of Building 29B was provided. The facility will be used for the production of master and production cell banks, pilot-scale fermentation and purification of bulk drug substrates. The CFR team has evaluated the current process, block layout and developed a User Requirement Statement (URS) document to establish scope and quality expectations for the project as well as support the feasibility, design and implementation logistics of the new Building 29B renovation. Work consists of the evaluation of existing process and a gap analysis against the proposed new space.

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NIH | BUILDING 10 6TH FLOOR A-WING LABS

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 2,500 SF

CFR provided MEP engineering design services for the renovation of labs 6A01(A) and 6A01(B) to accommodate the revised program requirements for the NIAID to include a BSL-2 level laboratory and work and support spaces.

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NIH | BUILDING 10 NIAA HOT CELL LAB

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 1,500 SF

The general scope of work was to create a new hot cell laboratory in the P2 level of the ACRF building. This space was originally a part of the parking garage. The project included relocating the parking garage supply air to be outside our area of work. CFR provided design for: utilities to 2 new government provided hot cells,  chemical fume hoods with all required utilities, a new lab sink and emergency fixtures, new exhaust fan motors on the hot cell exhaust system, and controls to maintain room pressurization.

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NIH | BUILDING 10 NIAMS 6D LABS

Client: CallisonRTKL 
Location: Bethesda, MD
Size: 5,000 SF

CFR provided MEP designs for Lab 6D44-50-52 renovations including new Mechanical, Electrical and Plumbing systems.   The project included modifications to the HVAC systems to provide proper cooling and ventilation, as well as a new UPS system and power distribution unit. The project involved 5 lab modules with standard bench top and casework space, and associated pluming and electrical utilities.  

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NIH  | BUILDING 4, ROOM B209 ORBITRAP MASS SPECTROMETER INSTALLATION

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 1,000 SF

The general scope of work was to provide construction documents for the installation of new power, HVAC, and plumbing to serve the new LTQ Orbitrap Mass Spectrometer and it’s accessories; as well as a new Quantum Thermo instrument.   Also included, was the evaluation of the existing HVAC systems serving the lab suite and to provide designs for supplemental cooling as necessary to provide the proper temperature control for the space and its new equipment.

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NIH | BUILDING 13 TRANS ELECTRON MICROSCOPE (TEMS) INSTALLATION

Client: The National Institutes of Health
Location: Bethesda, MD
Size: 1,000 SF

This project included the complete renovation of the G14 warehouse and adjacent silo storage space of Building 13. Design included a new mechanical room and a new TEMS microscope room which supports a Titan Krios Trans Electron Microscope. New work included a new vertical AHU which incorporated available chilled water and steam preheat with room steam reheat. New HVAC employs vibration isolation materials and equipment to mitigate sound and vibration transmission. CFR provided a new chilled water and steam piping which was routed outside of the perimeter of the microscope room, no piping was allowed to be run above the microscope. The fire protection system was modified to provide a fully functional sprinkler system. New lighting design and power system design were provided, which included electric service to the space provided by new panelboards. Design included new fire alarm devices to connect to the existing building system.

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NIH | BUILDINGS 10 & 50 VARIOUS LASER LAB RENOVATIONS

Client: The National Institutes of Health
Location: Bethesda, MD
Size: From 1,000 SF to 5,000 SF

Included the design of HVAC and electrical systems for various laser equipment utilized by researchers for the National Heart Lung and Blood Institute. Work included infrared lasers, argon lasers, water cooled and air cooled power supplies, and  laminar flow and HEPA filtered HVAC for precise laser measurement environments.

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NIH | BUILDING 10 5TH FLOOR CRC LAB RENOVATION

Client: NTVI Enterprises
Location: Bethesda, MD
Size: 4,000 SF

Project included MEP engineering design services for the renovation of the Building 10 Clinical Research Center 5th Floor. The Tenure Track Program will take place in the newly renovated research labs and support spaces. The new labs, which include two (2) tissue culture rooms, one (1) animal tissue culture room, two (2) cell storage rooms, and an equipment room, use an “open plan” design approach, sharing the support functions.  

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